II'll try to help but your post is missing a lot of detail. I use Windows 10 and Chrome with great success, so Windows 10 is not the issue.
Please confirm you've done the following and then tried to use Connect, so we can eliminate some variables:
2) Close all unnecessary applications.
3) In the Connect room, right click anywhere and choose Settings. Third icon from left (yellow folder icon), choose it and drag slider to the right all the way. Do NOT choose the checkbox. Close dialog box and you should never have to reset again.
4) Perform Meeting>Audio Setup Wizard.
Are you using VoIP or Audio Bridge?
Are you hard wired or wireless? Please provide your speed settings by going to speedtest.net to get upload/download times.
If you can try these things, and let me know how it works, We might be able to solve your issues.