I have a large document and I also have a one page document. I want to insert the one page document so that is becomes every other page of the big document. This so that I can print the full document double sided where one side of each print is the same but the other side is personalized.
Yes, you can do that with Acrobat, but there's no built-in function to do so automatically. You'll need to either insert the page manually, or to use a script to do it for you automatically.
One such script is this one I've developed, and which can be purchased from here: Custom-made Adobe Scripts: Acrobat -- Insert One PDF File Into Another Multiple Times