Could you please let me know the version of Lightroom installed on your computer?
Also which version of Windows are you working on?
And is the faulty module path:substrate.dll?
Lightroom 6.5, windows 7, it is substrat.dll.
Try the following steps once:
If you can't launch Lightroom, or Lightroom crashes before you can clear the Use Graphics Processor checkbox, here's how to manually disable this preference: