Moving everything back to C: resolves the problem...BUT...I still need to move the install folders to my E:. My SSd is nearly full and I need that space when I do deep sky stacking
The core installation of both the programs need to go on the system drive, C no matter where you actually want them to be. Moving folders is very dangerous as they are part of the installation as you have now seen.
Storing your photos on an external drive is the best way forward I would imagine in your case, but without knowing your setup would be a guess at the moment.
Photos don't exist in LR, they are referenced in the place they are stored, so stacking won't make any difference with your problem.
Come back with some more information, then we may be able to help you some more.
The only way to move the Adobe CC apps to some other drive than C is to do what you have done in the creative cloud desktop app then Uninstall all CC apps using the uninstall option in CC desktop app.
Then run the CC cleaner app
Then reinstall them. Note you might even need to reinstall the CC desktop app and make that drive letter change after that is reinstalled.
You should first backup all the LR catalogs you have, the LR & PS preferences, PS actions, LR & PS Presets and anything else you can think of that you need to carry over to the new install on your other HDD (whether it be the D, E, F or whatever drive letter.
Note that most of the things you are backing up will eventually be place back into the same PATH as where they came from (even if they were original on the C drive)
The Apps will still install some files on the C drive and specifically in your User Name folder and its sub-folders along with other folders.
But the Core of the program will be installed on the drive letter you have selected in the CC desktop app.
This is a Big mistake on Adobe's part.
I had to do the same thing as you when I first installed the CC programs.
Also let me point out you can't just move programs from one drive to another. 99.99999% of all Windows programs put entries in the Windows registry and other files all over the C drive that are looking for the actual program to be installed on the original install drive location, the original PATH.
There are only a few programs that you could do that with and again 99.99999% of the time they are listed as Portable programs. Meaning you can run them all by them selves for any drive even a USB thumb drive.