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Take a look at this: Who is Hogging My File? - KHKonsulting LLC
Your problem is very likely related to the preview pane. If this does not resolve your problems, please provide more information about what Acrobat version and operating system you are using.
Thanks very much Karl
Karl, what do you mean by preview pane? Change preview pane settings?
Did you look at the article? It's the Windows Explorer preview pane. You need to turn off the preview feature.