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You might want to return to Lightroom 6.5.1, lots of people are experiencing these problems.
Here are the instructions (use Lightroom 6.5.1 where it says 6.1.1)
Many thanks, I actually have a copy of the original installer stored, so managed a reinstall, along with a downloaded updater for 6.5.1.
Sadly that didn't fix the specific issues I was having. What has fixed it though is deleting all Smart Previews and not using them. I am now able to continue using GPU acceleration too.
I've no idea why that started happening all of a sudden. In any case, I think I'll stick with 6.5.1 for now, as it does seem a little smoother and snappier to use.
Just a quick update, more as some feedback really.
Since clearing the Smart Previews had finally fixed the problems, I decided to give it another go at 6.6, but using the standalone updater off the linked website you gave. I thought it was OK, but after a day or so, it started again, this time giving me a blue screen with the GPU acceleration on, and unresponsive adjustments with it off.
Back to 6.5.1 again, and all is well.