I am using Adobe CS5.5 without any trouble, excepted with Indesign.
I cannot use the mouse click for several tools (direct or indirect selection for exemple) that I can do with keyboard shortcut instead.
But I also have this problem when I want to select other functions that have no shortcup.
I already try to reinstall the programm several time, but it still doesn't work.
Is there any tool that would fix this problem?
Have you installed the 7.5.3 update?
What is your OS? CS5.5 is not supported on El Capitan and very well may have all kinds of problems.