Doing pretty much any action will work for a few seconds then freeze and not respond, and I'll have to shut down the program. I've uninstalled and reinstalled, I've used 4.5.2 as well as digital editions 3 with the same problem, so I think its a windows problem.
I've also tried enabling the app through the firewall settings.
After closing the app there appears to be a copy of the borrowed book in the library, but I am unable to copy it to my ereader (kobo) without it not responding and freezing.
I contacted my library and they in turn sent my problem on to Overdrive, here is their solution, it worked perfectly for me, good luck, let me know how it goes.
Thanks for contacting OverDrive Support Services. I'm sorry you're having trouble with this. Please take the following steps to see if it corrects the issue: