Are you using a web server such as IIS in front of ColdFusion? If so, what you want to do is fairly easy. If you are using the built-in web server, not sure it's entirely doable.
Yes, ColdFusion on IIS 8 . Can you help me with any link to instructions.
Create a new "site" in IIS, pointing to E:\InetPub\wwwroot (or whatever folder you want to use). Then run the ColdFusion Web Server Configuration Tool to connect ColdFusion to your new web site in IIS. This should add the CFIDE folder as a virtual directory to your web server.
I highly recommend following the ColdFusion 2016 lockdown guide. It covers these topics as well as many things that should be set to harden your server against intrusion/attack.