Just out of curiosity can you still use the keyboard shortcuts such CTRL/O or CTRL/N?
The disabled menus problem used to happen with slower drives/machines. Try disabling tabbed documents in Photoshop's preferences:
Uncheck "Open Documents as Tabs" and "Enable Floating Document Window Docking"
Hoping there is an easy explination as Adobe haven't replied to my facebook rant last year.
Did you expect a serious reply to a »rant«?
What are your OS and hardware?
What have you done for trouble-shooting so far?
Restoring Preferences after making sure all customized presets like Actions, Patterns, Brushes etc. have been saved might be a good starting point:
Disable any plugins you have installed as well.
Also what does task manager indicate when PS is in the non responsive state?
A reply would have been nice, but anyway...i uninstalled PS, AI & ID as i don't use these as much as PS, reinstalled PS and now works a treat, perhaps my hardware isn't what its cracked up to be.