This is more of a recent issue, all items within a document essentially lock up. Not like Object > Lock but you click on say a text box and try to click and drag it somewhere else and it doesn't budge. Now all the objects can be moved by clicking and using the arrow keys, but that takes forever and is ridiculous. The only thing that seems to refresh the document, allowing me to work again is to restart my computer.
I've trashed my preferences via going through the finder as well as the OPT + CMD + CTRL + SHIFT from the dock option to no avail.
Seems like I've had a similar issue in the past but with Illustrator and it ended up being a chrome extension I had installed that was causing the errors.