If I've picked up correctly what you are trying to achieve, then you could use Select - Color range to make a selection of the colour you want to change.
Then create a new solid color or gradient fill layer masked to show the selection you made in the step above.
Repeat for other colours you want to change
The advantage of doing this with new fill/gradient layers and masks is that none of it is destructive - you can change it all later
Thanks for your response, Dave. How do I make the mask you mentioned though? I've never worked with such a thing. Thanks!
A mask sits alongside a layer and where the mask is white the layer is visible and where it is black the layer is transparent, allowing the layer(s) below to show through. Grey is semi- transparent.
If you have a selection made and add a new layer using for example Layer - New Fill Layer - Solid Colour, then a mask will automatically be added to the new fill layer, showing the area you selected and allow the layers below to show through where you had not selected.
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You getting great advice from Dave, but I wonder if we might be able to better home in on what you want to achieve, if you showed us a screen shot. Right click the image and copy it. Then paste to this thread with Ctrl v.