Is your main hard drive full? By default PS uses your main internal hard drive as it's primary scratch disk. You need to clean out your hard drive. I had this issue the other day teaching in a lab - all the computers were full. I had to delete a bunch of junk on 13 machines so my students and I could get through the day.
My apologies for the late reply. My main hard drive info is as follows:
Capacity: 498.88 GB
Available: 54.84 GB
Used: 444, 039, 299, 072
Bytes: 444.04 GB on disk
Should I proceed to delete my hard drive?
You should definitely make room on your hard drive.