What version of E3D are you using?
What hardware (especially GPU) do you have?
When you say "activate" lights, I guess you mean set E3D to "use comp lights"? I'll guess that's yes since you are getting at least some of them to work.
Can you show a screenshot or something for the light set ups?
This has been answered in your duplicate post.
I am using E3D V2, GPU is Quadro 7000.
The card was actually installed in Opti plex 7000 , but i am using it separately so it is Quadro 6000.