Does turning off »Use Graphics Processor« in the Performance Preferences (Photoshop > Preferences > Performance > Graphic Processor Settings) and restarting Photoshop have any bearing on the issue? (But first try whether stepping back in the History can restore the affected Layers.)
What have you done for trouble-shooting so far?
Restoring Preferences after making sure all customized presets like Actions, Patterns, Brushes etc. have been saved might be a good starting point:
Hi! I did try to reset preferences and turn off the GPU. I didn't have any preferences on this machine, so it is a clean slate after the reset. I thought it was a refresh issue, so I closed the file without saving and restarted photoshop. But there are actually holes in each of the layers. It's as though I hit a short cut key for "screw up entire file." I don't understand how the holes could all be diffrent shapes.
I forgot to add that I did not step back in history. I wish I had....
If I remember correctly there may be faulty hardware involved at your computer, so you should run diagnostics if possible.
Otherwise proceed with general trouble shooting.
As for the damaged file itself you could try to see if the affected Layers maintained content under the transparency (Layer > Layer Mask > From Transparency, then disable the Layer Mask).
1 person found this helpful
I can delete the layer mask and then select and delete the white area.
Or you could paint in the »hole« in the Layer Mask with white, then apply it.
As for the actual reasons for this malfunction, that is beyond me … have you searched the Forum?
Maybe a thread about the same/a similar issue features a solution.
2 people found this helpful
A similar thing actually happened to me too, a couple of weeks ago, out of the blue. Once, never happened again.
It was just the layer mask, all the pixel content was intact, so all I had to do was paint it out in the mask. I wrote it off as a disturbance in the matrix and just moved on, but I'll keep an eye on it for the future.