I am running CS6 Design and Web premium. Dreamweaver and Photoshop interfaces look extremely small on my large 2560 x 1080 dell monitors. How do I enlarge the interfaces? Its very hard to use these this small.
Dw CS6 is not hi-dpi aware, but if you are using windows you can apply a system wide setting to increase the size of the UI. Unfortunately i think this would apply it to everything and not just Dw.
I can well imagine that it's hard to see. Legacy CS6 is not Hi-DPI aware and it never will be as CS6 is no longer supported.
The only thing I can suggest is changing your display settings to use a lower resolution. On Windows10, you can try increasing the scale % but this may cause some app panels to be truncated.
Modern Photoshop CC has a scale setting in the Preferences panel (see screenshot). But CS6 does not have this option.