Is your color problem with new document only or are colors in your old image files also effected? Have you reset all Photoshop Tools. Have you Reset you User ID Photoshop Preferences?
I have reset everything. It seems to only be new documents.
When you edit old documents and make changes to colors are the changes you make the correct color?
Can you show a screenshot of your color settings and also confirm the image mode of your new documents (that are giving you the trouble).
The reason I ask is that you say you are using North American General Purpose 2 but see a change when softproofing to sRGB. If you document is in RGB color mode (not CMYK), then North American General Purpose 2 uses sRGB IEC1966-2.1 as it's working RGB space. So soft-proofing to sRGB should show no change.