I'm on Windows 10 running the latest version of AE - I have 64gb ram, i7, SSD drives, Nvidia 1080
If I open After Effects from a fresh restart I'm able to load a project without issue but if I close that project and open another one I always get errors saying that plug-ins will not load. It's not just one plug-in, they vary and include native AE plug-ins as well as third party ones. The only way to open a new project is to restart the computer. I feel like there might be a memory leak that is causing an issue but that's just a guess. Any suggestions on how to fix my issue?
I would suggest uninstalling AE and reinstalling it.
If that doesn't help, you might try contacting Adobe support. They're usually pretty good at weird technical things like this. Make sure, if you go to Adobe.com/support, that you click on the Creative Cloud icon first (and not the After Effects icon, if one is there). That'll take you to the area to get tech support on current, CC versions.
Sorry for this issue. Did you ever find a solution? Please let us know if you have or if you still need help.