Ctrl Y to go into outline view to confirm your artwork si still there. Ctrl Y to get back to preview.
Save as you file to the .ai format, with pdf compatibility OFF (unless you plan on importing this into after effects or InDesign).
Your file may have gotten corrupted and the .pdf half was opened instead of the .ai half. In any case you should select item with the clipping make and object >> clipping mask >> release.
Your file will save quicker with the PDF off, and chance of corruption is greatly diminished.