Ideally you would have a third SSD for caching, but if you don't have enough space on your OS SSD then your Adobe apps SSD is probably the best option, especially if you're going to be using After Effects. You don't want to put your cache on a slow drive, and preferably not the same drive as the media either.
Like David suggests, it's best to have the OS and your apps on a single SSD. Apps/OS will work best if they're installed on the same drive. You may more easily run into problems if you install them on separate drives.
Perhaps you can choose to delete some games in favor of Adobe apps? Alternatively, is it an option to purchase a newer (larger) SSD and install your OS/Apps/Games on that drive, freeing up the existing drive?
For your media, I would strongly advise you to have a separate SSD.
Temp files should preferably be also on a separate SSD, I even have an m.2 memory drive for this purpose (I'm on PC).
I recommend first removing the games and any other non-editing software, then installing the Adobe suite on 1.
Put projects and Cache on 2, Media on 3, and Exports on 4.
Moved to the Hardware Forum.