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To support Windows you need DirectX. Both nVidia and AMD support DirectX
To get GPU Acceleration in Adobe Premiere the card must have either CUDA or OpenCL. nVidia cards with CUDA are better than AMD ATI cards with OpenCL. I just received PPBM results from the new 16-core AMD Threadripper CPU system tested with one of the latest cards from each vendor. The GTX 1080 Ti was far the best over the new AMD Radeon Vega Frontier Edition, and from the scoring on these tests I can tell you that you do not need a GTX 1080 TI to equal the results of the Vega card, it could safely be done with a GTX 1070 or maybe even a GTX 1060 6GB card.
Hey Bill - so I frequently have to edit RED Epic-W 8K raw footage. I just updated to the 16-core Threadripper and am using a 1080ti. When I render I generally have GPU heavy effects like Magic Bullet Looks/Cosmo II which appear to saturate the 1080ti (100% GPU usage during render times) while my CPU is 50% or under. This indicates to me that my poor 1080ti can't keep up with the CPU and wanted to ask if perhaps upgrading to the Radeon Vega Frontier Edition (because it has 16GB of ram) would help in this case?
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That Radeon Vega Frontier Edition won't cut it because of Adobe's historically poorer performance in OpenCL versus CUDA: The GPU utilization will still be pegged to 100%, while the CPU utilization will be no higher than what it currently is with the GTX 1080 Ti. Also, Adobe's CUDA renderer supports a few features that are not currently supported in the OpenCL renderer.
As a result, your situation is one of the very few that absolutely needs at least a second GTX 1080 Ti (though not necessarily SLI-linked).
If on the other hand the GPU memory (graphics RAM) usage is pegged to 100%, and then all of a sudden crashes down to its normal idle percentage in the middle of a GPU-accelerated rendering job (at which point the MPE renderer will automatically switch from GPU accelerated mode to software-only mode with absolutely no notification at all whatsoever), then a card with more VRAM might help.