I'm currently doing some illustrating using a combination of ArtRage Illustrator and Photoshop. Recently small fragments of the images I'm at work on are vanishing as well as fragments of the locked white background and the damage appears to be imbedded in the file. I'm using Photoshop CS6 on a 2012 iMac running Sierra.
Presumably compatibility issues. File corruption seems to becoming more and more of a concern. Perhaps you should just forego hardware acceleration and turn it off in the prefs... At least check those settings and change the mode to Basic. This may help.