Similar, very simple animations that i make with Animate and then in GWD differ drastically when it comes to performance on mobile. Lets say moving an object up and down with easing in a loop and then make it occasionally rotate some degrees here and there.
Made with GWD animations runs perfectly smooth on mobile phones, the animation made with Animate run like 0-2fps.
If you use Motion Tweens, or you use Classic Tweens but change the easing graph, it will perform very badly. Using one of the many ease presets, and just giving it a strength of -10 to +100, will give you good performance.