In class we use Muse 2015.2, but at home Muse 2018. Will there be any issues when I submit a file from Muse 2018 to Muse 2015.2.
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Yes. You can‘t open it. You can‘t open a .muse file in a Muse version, which is older than the version, which you used to create it.
also 2015 and 2018 are night and day when it comes to web design... if you convert a web site from 2015 into 2018 then expect it to jumble the design