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here are somethings:
1) Understanding of HTTP request/response cycle
3) Some server side technology for web apps: PHP, JEE, .NET (to get your data primarily)
2) Flash player plug-in in a web browser
You can start to learn Flex without most of these, but they will greatly help. You can also start learning Flex and start to learn those other topics side-by-side. With absolutely no knowledge of those topics, Flex study might be tougher than desired, as you want to study Flex, move forward in your knowledge and application of it, and thus get more and more excited about what Flex offers and how huge it will be in the next five to ten years. But not having all those areas, and not to a high level, should not deter you from delving into Flex.
What does Flex exactly do? Not to sound dumb?
Flex allows you to create "rich internet applications". Usually a web page has links that when clicked, return a new page every time. Also, standard web pages do not allow you to create truely great visual environments. Flex allows you to provide a better overall experience, perhaps by keeping them in one page, that does not completely refresh each time a link is clicked, or data is sent to server.