Could you please try the steps mentioned below: -
Quit Photoshop, then press Command + Option + Shift on cold-starting Photoshop. Get the keys down quickly enough and you'll be asked to confirm deletion of your current preferences.
Also, if you're having file format problems, ensure you haven't somehow tied in plug-ins provided by Adobe for a different (e.g., older) version of Photoshop.
You could try Lockhunter. I've used it many a time to get rid of those annoying dll etc's that some software companies think we want left cluttering our hard drives with no way to remove (sans Lockhunter type programs). It'll show you what is locking it and in some cases I've had more than one culprit locking them. Hasn't failed me yet. Might be worth a try to save you having to do a re-install.
I think Command option shift is for an apple, I don't see those keys. I have a PC. I tried ctrl, alt, shift but that had no effect.
What should I do for a PC with Windows 10?
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I just use 'Save As' and save with a different name, then sort out the conflict later. You can't close and restart Photoshop, because you'd lose your work!
Sometimes it might not be obvious that the file is open, or being used in another application, so with Windows, we look at the hidden icons in the Task Bar. The sort of situations that can lead to this is if you opened the image from and email application, and the email recognizes that it has changed. Alt tabbing through active windows might find a 'Save Changes' dialogue'. I have no idea how this works on Mac systems.
I found the answer on another thread. It was the anti virus causing the problem. I uninstalled Avast and now I can save. Problem solved.