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When ever I save RAW files as psd and perform some processing steps huge files up to 200 MB arise, even after I
waste levels have deleted and reduced to a single layer. Now I wonder for a long time, if there is a way to minimize the file size of a psd without losing image quality from a single plane consisting of.
To export the files to a compressed file type is not the debate, as this for me lost important metadata.
Raw files are one channel grayscale files, and will always be much smaller than rendered psd or tiff files.
If you have a 36 megapixel camera, and save a 16-bit psd or uncompressed Tiff, the file size will be around 200 MB.
Raw files from my Nikon D800E are around 45 MB, and a 16-bit Tiff will be around 200 MB. If I use ZIP compression when saving the Tiff, file size will be reduced by 10 - 15%.
Saving as 8-bit Tiff will result in half the file size (100 MB), and using LZW compression will reduce the file size considerably.(depends on image content, but maybe down to 40 MB or even less)
Both ZIP and LZW compression are lossless.
You could also save as jpg, which will not delete metadata.
I've written a couple of articles that you may find helpful: