One way would be by recording actions that clear guides then set guide then set guides relative to the dcument's size. Actions to set guide dividing grids or some layout like a picture collage.
Do you know that you can save New Guide Layouts? If you check Clear Existing Guides then I 'think' you can use an Action to apply a specific new layer out, and assign an easy keyboard shortcut to it.
Always remember that you can save keyboard shortcuts with custom Workspaces, so you can 'borrow' a shortcut from something you don't often use, and go back to the Essentials workspace when you need the defaults.