Can you give more information the exact error message you're getting? feel free to copy and paste it here.
When you click in application icon to run it, inmediately press Ctrl + Alt + Shft in Windows or Cmd + Alt + Shft in Mac. Both to delete your preferences. This maybe resolves your issue.
Tell us if so, if not, upload a screenshot of your error message.
Thanks guys. Deleting my preferences did not fix it. When I double click to start the application, the Mac "pinwheel" spins for 2 seconds, the After Effects purple triangle start screen appears and - immediately after it does - the error message "After Effects can’t continue: unexpected failure during application startup"
The error message doesn’t say much more either. In this case we don’t have another choice that unninstall it and delete preferences, restart your computer and then install it again. Some system file is corrupt surely in the application and making this you gonna have a new and clear AE.
Before unninstall it try updating from Creative Cloud Desktop App.
Help Help Help - I'm experiencing the exact same issue / error message when trying to launch After Effects CC 2018 with my MacBook Pro Late 2016 MacOS 10.13.3, 16GB RAM, Radeon Pro 450 2 GB Intel HD graphics 530 1536 MB graphics card. I need to render a video that's (of course) already past due . . . I simply want to launch After Effects which was *******' working perfectly 2 days ago . . .
Help Help Help!!!
I Literally spent 6 hours on the telephone with Adobe tech support & watched while they explained and screen shared (controlling) my computer. After four (4) conversations, uninstalling, reinstalling, removing permissions, manually deleting preferences folders, yada, yada - No Fix. I was asked to make sure my computer updates were current.
AE is totally unusable for me on this computer . . .
I'm using it on another computer (my work machine) . . .
Help Adobe - You're My only Hope!