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Anything from entering Time Machine? It sounds like MacOS from the terms you use.
I'll have to test it out later on, but I'm not sure if the file had been backed up recently (my fault - I know). Can you think of any other the place the file could have been secretly stored if the psd. file had been saved on my desktop and mysteriously disappeared?
There's many reasons because it is a common problem.
Here's a Google search string: "file vanishes from Mac Desktop" Many articles giving you an idea where to look and commands to try.