Have you tried resetting Photoshop preferences
To restore preferences quickly using a keyboard shortcut: Press and hold Alt+Control+Shift (Windows) or Option+Command+Shift (Mac OS) as you start Photoshop. You are prompted to delete the current settings. The new preferences files are created the next time you start Photoshop
Wasn't able to get the shortcut to work but directly went into appdata and edited the old preference files, this seems to have solved the problem, Thank you!
In the interest of my own curiosity, is there any understanding of why the preferences would be causing PS to not respond?
Update: While deleting the preferences worked for a short period it has once again begun not responding after being used for only a short period on the intuos. Re-deleting the preferences has not helped.
An interesting note that may or may not be helpful: any file opened before it goes into "not responding" will later not show up on the "recent files" list in photoshop cs2.