I have AcrobatPro DC (Continuous Release 2018.011.20040) Mac Sierra (I can't upgrade per corporate's IT just yet)
I cannot get ANY of the keyboard shortcuts found on this page Keyboard shortcuts for Adobe Acrobat to work at all.
All I can do is 4 common ones, copy, paste, save, close. I would LOVE to be able to marquee zoom or switch to select tool by keyboard, or even assign shortcuts would be a great help. I'm not sure why Command+spacebar to select an area to zoom into doesn't work universal across all Adobe platforms.
As per the issue description mentioned above, keyboard shortcuts not working in Acrobat, could you check if single key accelerators option is turned on by opening the Preferences dialog box (Edit > Preferences), and under General > Use Single-Key Accelerators To Access Tools. If its not, try enabling the option and check if that helps.
Let us know if you need any help.
Who knew "Single-Key Accelerators" is the new Adobe term for "Keyboard Shortcuts"