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As per the issue description mentioned above, you want to change the default open option in SharePoint Online, is that correct?
As you are opening a pdf file in a sharepoint online site in a web browser, could you try contacting Microsoft and see what they have to suggest.
Sure I can reach out to Microsoft - thought I would try Adobe first since it is an Adobe integration into SharePoint.
3 people found this helpful
Just an FYI - I came across this today - apparently the #2 most voted feature in the SharePoint UserVoice forum for Sites and Collaboration! Hopefully it is resolved soon and wanted to share as there is another helpful workaround with mapping a drive.