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Most of us probably work with multiple media sizes these days. Fact of life, right?
So when setting up for a new project sequence, you need to think of your media, and puzzle out which frame-size/rate is the best fit for your media. As always, upscaling media to a larger frame-size can be dicey, but down-scaling gives options to even 'crop' without losing resolution.
So ... what it the smaller frame-size for the majority of your media? That's probably the frame-size to use. Say you've got 1080 and 4k media ... with a large amount of 1080 ... well, probably a 1080 sequence is best.
Frame-rate ... again, primary rate used in the media is normally a good starting point.
If you have media that it both at the 'correct' frame-size & rate, you can start a new sequence by say just dropping one of those clips in the blank timeline area. This creates a sequence to match the media.
PrPro can adapt other frame-rates to the rate of the sequence in many cases, in some you may need to adjust with perhaps Modify/Interpret Footage to set the frame rate for some clips.