I have the same issue and it's VERY annoying and totally unacceptable! I run Acrobat CC on two different PCs - one Win 7 and one Win 10. Which filesystem you run I believe is irrelevant as I'm having NTFS on both.
On disks with NTFS I have no problems.
Solutions proposed in other topics didn't help.
Sorry for the delay in response.
As per the issue description mentioned above, Acrobat is creating gpu cache folders in a folder when opening a pdf, is that correct?
Could you check if you are running the latest version of Acrobat using "Check for updates" option under "Help" menu, You may also download updates from here: Adobe software and product updates
Reboot the machine after installing update and try again.
If that doesn't work, try the troubleshooting steps given below:
1- Download and run cleaner tool on the machine to uninstall Acrobat: Download Adobe Reader and Acrobat Cleaner Tool - Adobe Labs
2- Reboot the machine
3- Download and install Acrobat from here:Download and install Acrobat DC subscription
4- Reboot the machine again and check.
Also, let us know dot version of Acrobat and the operating system installed on the machine? You may refer to the steps given in this link on how to check the version in Acrobat: Identify the product and its version for Acrobat and Reader DC
Let us know if you need any help.