So basic hotkeys like "Cut" and "Deselect all" don't work anymore...

[Mobius Strip]

Just updated to 20.0.0 and loaded up an image to test the new scaling defaults, and found that Command-X doesn't do anything, and neither does Command-D.

WTH?

UPDATE: This appears to be a bug that afflicted the app temporarily; I don't know if switching focus to another app jostled it out of its funk or what.

UPDATE 2: There's definitely something up with the application's state. Just now, Quit and a large number of other menu items were disabled, and nothing was going on in the app (no operation in progress or something waiting for confirmation).

[JJMack]

I do not have problem on my windows 10 version 1809 and CC 2019 version 20 on my machine with those Photoshop shortcuts.  In the past I thin Focus has been taken from Photoshop and Shortcuts do work at time. This could till be a problem.  Menu items are grayed out by Photoshop when the current  document state does not meet the requirements for their use.

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[Mobius Strip]

Thanks for the replies.

This is on Mac OS 10.14

There was nothing going on in the application that would have left the document in a pending state. I opened a bitmap (photo) and it was sitting there. I could draw a selection rectangle, but Command-X didn't copy and Command-D didn't deselect. I imagine there were lots of other hotkeys that didn't work.

Later, after I made the original post, I went back and these functions magically worked. But a short time later, Quit was disabled as were lots of other menu items; again, I hadn't done anything to invoke a pending state in the document. Photoshop was probably in the same state I experienced the first time.

You mentioned having the program become unresponsive, and I thought I'd document these issues in case they're related.

There's no further information at this point. There was no identifiable impetus for the failure or the recovery.

[gener7]

I'm not clear if you tried the reset or not. Did it work?

[Mobius Strip]

No, because this problem has come and gone twice with no discernible pattern. If it ​stays ​broken, I will consider it.

[gener7]

When you mention the Command key, I instantly know it's a Mac and Cmd D works as advertised on 10.13.6 and the newly released 10.14 (Mojave) on the 20.0 Photoshop.

Right now you can try a Preferences Reset. But do come back with more information if that doesn't work.