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Check to see if you actually have an ASIO driver for your Mobile Pre. If not, then go to M-Audio's site and download the latest driver for your device.
The Mobile Pre works well with Audition when using the ASIO driver from m-audio.com. Unfortunately, I don't think they've released a Vista comaptible ASIO driver, and last time I checked, they didn't intend to. If you're using Windows Vista, you may need to use the ASIO4ALL driver if you want a little better performance then the default DirectSound wrapper provides. You can find this at www.asio4all.com.
A check of the M-Audio site confirms that they have available a beta version of a Vista-compatible driver for the Mobile Pre USB.