If you are fixing this on just one system just do this.
1. Right Click the AcroRd32.exe in the Adobe 9 install directory.
2. Go to the compatibility tab and check "Run this program in a compatibility mode for:" choose Windows XP SP2.
3. Adobe Reader 9 should work just fine now.
If you are fixing this for your enterprise you just need to create an application compatibility fix with just one fix and push this out with Adobe Reader 9.
1. Download and install the Microsoft ACT Toolkit for Windows Vista.
2. Open the Compatibility Administrator and create a new application fix for Adobe Reader. I will let you read the documentation on how this is done.
3. The only compatibility fix that you need to apply is the WinXPSP2VersionLie.
4. Install the compatibility fix and Adobe Reader 9 should work just fine now.
I cannot put into words how ridiculous that it is this problem has not been fixed by Adobe.
Post back if this helped.
You can also try changing the default installation path, it worked for me once. By the way which reader version are you using.
We currently have deployed Adobe Reader 8.1.2 soon to upgrade to 8.1.4.
I have been testing the Adobe Reader 9 versions but both 9 and 9.1 have the runtime problem.
I had the exact same problem - after checking several websites and trying different things, what worked was clicking on the help button before the runtime erorr popped up and selecting check for upgrades. I downloaded the upgrade and can now get in the Adobe with no problems.
When you have this issue when logging in with a roaming userprofile on a W2K8 Terminalserver then this is the:
The LocalLow folder is not created on the Terminalserver. Therefore, any applications that access the LocalLow folder may fail.
Get the following Microsoft HOTFIX and install it (just fill your e-mail adres and MS sends you the hotfix)
(BE SURE! To open above link from an 2008 server!)