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Addendum: I now recall when things went south. It was when I installed the 8.1.2 update.
I was able to open Adobe Reader using a different admin account, so I exported the HKCU/Software/Adobe key and subkeys to a .reg file. When I logged into my usual admin account, I could not merge the .reg file.
Turns out the HKCU/Software/Adobe/Adobe Reader key was locked for some reason. My admin account only had Read permission for that key and its subkeys. So I right-clicked the key, clicked Permissions, clicked Advanced, and changed the permissions for the Administrators group to Full Control. I then repeated that process for all of the subkeys.
After that, I could merge the .reg file, and Adobe Reader worked fine.
W. Scott Simmons
Please provide detail on where to find HKCU/Software/Adobe/Adobe Reader key and how to meege reg file.