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Mmh, there isn't really any secret to this. The default 60/ 120% combo is mostly considered to be the best compromise in most situations. AE's memory allocation is dynamic, anyways... If it's of any importance to you, you might increase the average RAM usage to 80% or so, but unless you work with larger comps that benefit from that setting, you won't see much of a difference.
Depending on the type of work, you can also go to the other extreme and lower the RAM usage, but instead use the disk cache. It will force AE to dump more frames to disk rather than holding them in RAM. This can be beneficial if you are using many precomps with effects or do color space conversions e.g. working with 32bpc OpenEXR files in 16bpc or something.
For the purging you shouldn't overdo. Emptying the memory every 5 or 10 frames can be enough many times. Only use lower values if your comp doesn't go thru at all. The downside to purging is that AE needs to load everything from scratch after a purge and depending on the amount of stuff, this can drastically increase render times. So it's not always wise to use this option. It will be even more so, if you are using temporal trickery with time-remapped comps or effects such as Echo or CC Force Motionblur.
The "Secret" purging is secret because it is only needed in very rare circumstances with codecs that have memory leaks and other problem-solving tactics. Using the secret purging will cause your renders to be up to 100 times slower, so be careful and remember to turn it off when you have solved your problem.
- Jonas Hummelstrand