The following response came from offline discussion with Duncan Rosie, who had researched it earlier and attempted to post the solution here.
Thank you Duncan! You saved my hide!
Now the solution – this came from Andrew Chemey, one of Adobe’s Community Experts.
The “LMSInitialize() never invoked” problem is with the Adobe Flash Player security sandbox. Flash Player (later versions like 7 and above) prevent by-default, Flash-based files from communicating to JS (the HTM wrapper) when launched locally (e.g. if you double-click on an HTM file from your desktop).
To get this to work the Flash security settings need to be changed:
1. Launch *any* Flash-based file in a browser (e.g. double-click on an HTM file that contains a reference to a ).
2. Right-click on the Flash file
3. When the short-cut menu appears, click on "properties" – this is Flash version dependent, the pop-up may say “settings”.
4. Click the "advanced" button in the properties pane. This should open a new browser to Adobe.com
5. Click the "Global Security Settings" link on the left-side of page.
6. In the security settings panel, click the "Always Allow" radio button; and
7. Click the drop-down arrow next to "Edit Locations". Select the "Add Location" link
8. In the text entry pane - manually type the location (I am assuming that in your case it will be to the server where the material is run from, for me it was my local hard drive).
9. There is no Save or Confirm – I browsed through the other settings and came back to Global Security Settings and the settings were retained.
10. Close all browsers and relaunch the content from the ADL .