I have indexing OFF on all drives... it slows things down, from what I've read
Make sure that indexing and compression is turned off on all disks. Responsiveness of your system will improve noticeably.
I would use the following disk setup:
1. C: OS & programs, including Adobe and Outlook.
2. D: Pagefile, fixed to 8 GB (min=max), media cache, scratch or preview files and project files.
3. E: media and exports.
I assume you have the stock Intel CPU cooler? If so, you can improve your cooling by getting a special CPU cooler like the Noctua NH-U12P with push-pull configuration, or the Thermalright Ultra-120 Extreme, or similar.
In your PM you alluded to slight overclocking to around 3.2 GHz. To achieve that set your BCLK in the Bios to 160, instead of the default 133. Leave everything else on default. Now check with CPU-Z that your bus speed is 160, your core speed is around 3280 MHz and the multiplier is 21. Next check the temperatures in your system using both HWMonitor and Speedfan (use the Exotics tab and click Show the Magic button). On this page the Frequency will be shown as 3200 MHz, because Speedfan uses the standard multiplier of 20, while CPU-Z uses the turbo mode multiplier of 21.
The temperatures should hardly go up when overclocking, maybe 3 degrees or less while idle and should be below 45 degrees.
I also suggest you go through the Services section in the Optimizing and Tuning Guide that I linked to earlier, because that will lower the overhead of Windows and improve system performance as well.
If you want, you can post screenshots from CPU-Z, HWMonitor and Speedfan, so I can check your settings as well.