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You do not need LifeCycle nee Flex Data Services, but you can use it
with ColdFusion the same as any other J2EE application server.
But you can also use Flash Remoting, Web Services and|or HTTP requests
to interact with a ColdFusion back end from your Flex front end.
The choice is up to you on what you are comfortable with and the
requirements of your application.
You don't need to use LCDS if you want to use HTTP calls or SOAP web services over HTTP. So if you're going to call your cold fusion page via HTTP no problems.
Check out mx.rpc.http.
If you use ColdFusion 7.0.2 or ColdFusion 8, you can RemoteObject to exchange data with CFCs. It is easy and Flex Builder has some CF wizards to help you out or at least get you started. You'll want to reduce your use of CFMs since your Flex app will replace most of them.
If you check on my blog (weblogs.macromedia.com/pent) and search for ColdFusion you'll see a couple of examples.