Maybe not. When you install Adobe Reader in your computer, the rigister information is automatically typed on Registry. You need that to open your adobe reader when your want to open PDF. So it is impossible to do that. of course, you can add a setup program in your disk. If your friends' computer do not have adobe reader, he could install it briefly.
Adobe Reader must be installed on the system in my opinion.
What you want is Sumatra http://portableapps.com/apps/office/sumatra_pdf_portable
Foxit Portable http://www.pendriveapps.com/foxit-portable-pdf-reader/
There are a few dozen others, but those two are the best for running from a Flash Drive. Persoanlly, I prefer Sumatra.
Thanks I shall try these suggestions.