AIR uses a garbage collection system. It won't necessarily free memory right after you close a window.
You can trigger the garbage collector manually to test whether you have a memory leak. See the System.gc() function (http://help.adobe.com/en_US/air/reference/html/flash/system/System.html#gc%28%29). Generally to avoid memory leaks, you need to avoid keeping unneeded references to objects.
Some useful articles:
The Aptana plug-in for AIR now supports profiling: http://www.aptana.org/air/
How does APTANA studio works. Currently I am using eclipse for AIR applicaiton development.
Is APTANA a plug-in on top of eclipse or support IDE.
Pl. throw some light on this.
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I believe it is an Eclipse plug-in. You should be able to get all the details from their web site.
If you want, you can download the stand-alone version of Aptana.