Yes, you could, but it's a manual process. And if you ever update Camera Raw, you'll get all the other color & lens profiles installed again.
Please let me know if you're still interested, and I'll provide the steps.
The hesitation on my part is because I doubt that removing them will actually provide a real-world benefit (that is, you may spend more time removing them over time, than had you just left them there ...)
Thanks for you help Eric. I thought the answer might be something along those lines. Sounds kind of futile for a relatively small saving in hard drive space. A very quick search of my /Library/Application Support/Adobe/CameraRaw folder shows that if I remove all of the camera/lens data for models I will never use, it would free up 186.5 MB. But then it would come right back....
Thanks again. Have a great day!