I have read through a bundle of solutions to this problem and haven't found anything that has worked yet. I ran After Effects and Premiere Pro on Vista up until two days ago when it refused to open. When I try to open Premiere, it gives the message "Sorry, a serious error has occurred that requires Adobe Premiere Pro to shut down. We will attemp to save your current project." When I tryo to open After Effects, the firts try does nothing. The second attempt will open After Effects, but all interfaces are missing and all the dropdown menus are grayed out. When I close it, it says After Effects has crashed, contact support, error 0:42. I have uninstalled/deactivated and reinstalled, run codec sniper, removed xmi preference settings and nothing works. Does anyone have any suggestions?