This hasn't been much of an issue since CS3 so please tell us what version of AE you're using and your platform/OS details.
I agree with David. Without further info, you have just wasted 2 minutes of your life writing a meaningless post. a 0::42 is just a generic crash and has no intrinsic, specific reason. There could be any number of reasons for this, from bad CoDecs to graphics issues to flakey third-party plug-ins. So provide as many details as you can.
Do you have OpenGL enabled? If so, try disabling it.