ADE is trying to do an HTTP post to the URL indicated in the E_ADEPT_IO error message. Unfortunately I'm not familiar enough with your firewall to suggest a setting that would allow that.
I'm afraid there was no URL included in the error message (or if there was it wasn't part of the error message itself). I could probably check Vipre's log to see if I can spot it there. Knowing that ADE was trying to do an HTTP post might be enough for me to contact the Vipre software people and ask them what I need to adjust.or change.
Ctrl (or Cmd on Mac) Shift - T will bring up a dialog to let you turn on error logging. This will dump the text of the errors to a file named error.log in your (My) Digital Editions folder, and may contain the URL (but then again it may not).