I think I found a Windows setting that is causing the issue. I'm using
my LCD HDTV as the monitor for this computer, and in order to see the display easily, I have the following setting in Windows 7: Control Panel > Appearance and Personalization > Display > Make text and other items larger or smaller > 150%.
When I change this to the default of 100%, the problems with Reader X in Firefox and IE disappear. Reader 9, however, works perfectly at 100% and 150%.
Is this a known bug in Reader X? Since the problem only appeared when moving from Reader 9 to Reader X, it seems it's not an unsolveable incompatability or something that's too difficult to work around.
Do any others with their displays magnified have this problem? Or does it work perfectly? Would anyone (preferably with Windows 7 64-bit) be willing to set their display magnification to 150% and see if they can replicate the problem?
I can reproduce the problem on my Win7 32-bit too. The toolbars do not work after I changed the display setting to 150%. I, however, can use the context menu items just fine. The problem goes away when I turn off Protected Mode in Reader (Preferences > General > uncheck "Protected mode at startup"). Are you sure that the toolbars do not work after you turn off protected mode in Reader?
I know this is an old thread but the exact same thing was happening to me and I believe I found a resolution. I have my Win 7 text size set to 135% magnification. The way I resolved this issue was:
1) Right click the Adobe Reader X icon in the start menu
2) Click properties
3) Click the compatibility tab
4) Turn on the option for "Disable display scaling on high DPI settings"
5) Click on apply/OK
You may then have to reboot.